Immunoreactive adrenomedullin in human plasma

Immunoreactive adrenomedullin (AM) concentration in maternal plasma during human pregnancy and AM expression in placenta.

Adrenomedullin (AM) is a novel vasorelaxant peptide, isolated from human pheochromocytoma. Although AM may be involved in the regulation of the cardiovascular system, a number of other mechanisms are also involved. The present study was undertaken to confirm the presence of AM in human maternal circulation and in placental function during pregnancy. Immunoreactive (ir) AM concentrations in mate...

True versus immunoreactive angiotensin II in human plasma.

To measure specifically angiotensin-(1-8)octapeptide, peptides were extracted from 2 ml of plasma by reversible adsorption to bonded-phase silica. The angiotensin-(1-8)octapeptide was then isolated by isocratic reversed-phase high-performance liquid chromatography and quantified by radioimmunoassay. The extraction recovery of 125I-angiotensin II added to 2 ml of plasma was 99 +/- 2% (mean +/- S...

Plasma adrenomedullin in acute ischemic stroke.

Nature of plasma immunoreactive glucagon in man.

Since an immunoassay technique was first applied for measurement of glucagon, many studies on circulating glucagon levels under various conditions have been conducted. Their results, however, are not necessarily unanimous, as suggested by the fact that more than twenty fold differences in plasma immunoreactive glucagon (IRG) values in fasting healthy subjects have been reported. (Schalch, 1966;...

Plasma adrenomedullin in various diseases and exercise-induced change in adrenomedullin in healthy subjects.

Adrenomedullin is a novel hypotensive peptide recently discovered in human pheochromocytoma. In the present study, we measured the plasma immunoreactive adrenomedullin of healthy subjects and patients with various diseases. Immunoreactive adrenomedullin was found to circulate in blood of the healthy subjects at a considerable concentration (3.3 +/- 0.3 fmol/ml). Plasma adrenomedullin was signif...